Heart Development

DRUGS Stuff

Formation of the Heart Tube

- cardiogenic field
- endocardial tubes
- Folding of the embryo
- fusion into a single primitive heart tube
  • The morula is a solid ball of cells, with around 16-32 blastomeres
  • It is still surrounded by the zona pellucida
  • No cavity has yet formed

Primitive Heart Tube Regions

- Truncus arteriosus
- Bulbus cordis
- Primitive vnetricle
- Primitive atrium
- Sinus venosus

Cardiac Looping

- Rightward looping
- Establishing L/R orientation

Septation of the Heart

Atrial septation Septum primum Foramen primum Foramen secundum Septum secundum Foramen ovale Closure after birth Ventricular septation Muscular septum Membranous septum Endocardial cushions Atrioventricular septation Endocardial cushions Division into mitral and tricuspid valves

Cardiac Looping

- Rightward looping
- Establishing L/R orientation

Outflow Tract Development

- Conotruncal ridges
- Spiral aorticopulmonary septum
- Separation into aorta & pulmonary trunk

Valve Development

- AV Valves
- Semilunar valves
- Endocardial cushion

Fetal Circulation

- Umbilical vein
- Ductus venosus
- Foramen ovale
- Ductus arteriosus